Ono is one of the cities founded by the sons of Elpaal.
1 Chr 8:12The sons of Elpaal were Eber, Misham, and Shemed, who built Ono and Lod with its surrounding villages.
During the post-exilic period, descendants from this place returned and resided there.
When Nehemiah (governor) was rebuilding the wall, adversaries like Sanballat and Geshem tried to lure Nehemiah to this place with the intention of harming him.